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Sleep Med Res > Volume 13(1); 2022 > Article
Sleep Medicine Research 2022;13(1): 38-45.
doi: https://doi.org/10.17241/smr.2022.01207
Effects of Melatonin on Sleep Quality and Disease Activity in Patients With Rheumatoid Arthritis
Tayebeh Palimi MSc1 , Marzie Zilaee PhD2 , Elham Rajaei MD3 , Majid Karandish PhD2
1Department of Nutrition, School of Allied Medical Science & Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Corresponding Author: Majid Karandish ,Tel: +989166181688, Fax: +986133738330, Email: mkarandish@yahoo.com
Received: February 13, 2022.  Revised: April 12, 2022.  Accepted: April 19, 2022.
Abstract
Background and Objective     In rheumatoid arthritis (RA) patients sleep disturbance is one of serious and prevalent problems. Considering the known effects of melatonin on sleep quality and inflammation, this study aimed to investigate melatonin supplementation effect on quality of sleep and disease activity in patients with RA.
Methods     In this randomized, placebo-controlled trial (double-blind), 64 RA patients were selected and divided into experimental and placebo groups randomly; experimental group received 3 mg/d of melatonin and another group consumed placebo for 60 days. Before and after the investigation, assessment of the quality of sleep determined using the Pittsburgh Sleep Quality Index (PSQI). Disease Activity Score-28 (DAS28) and the Visual Analogue Scale (VAS) questionnaires were used for evaluation of disease activity and pain intensity, respectively.
Results     Melatonin significantly reduced PSQI, DAS28 and VAS scores, when values compared with baseline. In contrast to placebo group, good sleep quality within the melatonin group increased significantly compared to baseline and this improvement in sleep quality was significant when compared between groups. The scores of DAS28 and pain VAS at the end of trial were significantly reduced compared to the baseline in both groups. However, reduction in the DAS28 and VAS scores of the melatonin group were stronger than reductions in the placebo receiving group.
Conclusions     This study results revealed that melatonin was safe and effective in improving sleep quality and reducing DAS28 and pain VAS scores in RA patients.
Key Words: Melatonin; Sleep quality; Rheumatoid arthritis; DAS28